- Product Details
Keywords
- T0901317
- T-0901317
- high purity and best price
Quick Details
- ProName: T0901317
- CasNo: 293754-55-9
- Molecular Formula: C17H12F9NO3S
- Application: For laboratory use only- not intended ...
- ProductionCapacity: 1 Kilogram/Month
- Purity: ≥98%
- Storage: room temperature
- Transportation: by air
- LimitNum: 10 Milligram
Superiority
Details
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively, inhibits nuclear factor/κB (NF/κB) target: LXR, FXR; IC 50: 50 nM and 5 μM. In vitro: upregulates the expression and activity of TM, T0901317 treatment inhibits nuclear factor κB (NF/κB) signaling and the secretion of high glucose induced proinflammatory mediators, including tumor necrosis factor α and interleukin 1β in GECs. T0901317 enhances the interaction between LXR α and the transcriptional coactivator, p300, in GEC extracts. In vivo: The reference dose is 10mg/kg/d. You can dilute the product in 0.5% carboxymethylcellulose. Administration of T0901317 does not lead to severe myocardial lipid accumulation in rats despite of its high plasma availability. Administration of T0901317 to high-fat fed rats augments diet-induced hyperlipidemia. T0901317 completely restores glucose transporter 4 expression and insulin-stimulats Akt substrate of 160 kDa phosphorylation in all investigated muscles