Keywords

• EPZ-015666,GSK3235025;EPZ-015666;GSK-3235025
• high purity EPZ-015666
• high ee value

Quick Details

• ProName: EPZ-015666,GSK3235025;EPZ-015666;GSK-3...
• CasNo: 1616391-65-1
• Molecular Formula: C20H25N5O3
• Appearance: white powder
• Application: just for experiment.
• Port: shanghai
• ProductionCapacity: 100 Gram/Month
• Purity: 99% purity, 100% ee value
• Storage: -20℃ for 3 years
• LimitNum: 1 Gram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details

EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
IC50 value: 5 nM (Ki) 
Target: PRMT5 inhibitor
EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models.