HTH-01-015 CAS NO.1613724-42-7

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HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). IC50 value: 100 nM [1] Target: NUAK1 HTH-01-015 did not markedly suppress the activity of any of the other 139 protein kinases evaluated. Treatment of cells with 10 μM HTH-01-015, the NUAK1 isoform selective inhibitor, only led to a partial inhibition of MYPT1 phosphorylation. In HEK-293 cells expressing wild-type NUAK1, concentrations of 3–10 μM WZ4003 or HTH-01-015 markedly suppressed phosphorylation of MYPT1.