Keywords

• HTH-01-015
• best price
• Chengdu Henghui Pharm Tec Co. Ltd

Quick Details

• ProName: HTH-01-015
• CasNo: 1613724-42-7
• Molecular Formula: C26H28N8O
• Appearance: yellow powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 100 Gram/Month
• Purity: ≥98%
• Storage: room temperature
• Transportation: by air
• LimitNum: 10 Milligram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details

HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). IC50 value: 100 nM [1] Target: NUAK1 HTH-01-015 did not markedly suppress the activity of any of the other 139 protein kinases evaluated. Treatment of cells with 10 μM HTH-01-015, the NUAK1 isoform selective inhibitor, only led to a partial inhibition of MYPT1 phosphorylation. In HEK-293 cells expressing wild-type NUAK1, concentrations of 3–10 μM WZ4003 or HTH-01-015 markedly suppressed phosphorylation of MYPT1.