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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Business Type:Lab/Research institutions

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Year Established:
2017
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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

GNE-3511

CAS NO.1496581-76-0

  • Min.Order: 10 Milligram
  • Payment Terms:
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Product Details

Keywords

  • GNE-3511
  • GNE3511
  • GNE 3511

Quick Details

  • ProName: GNE-3511
  • CasNo: 1496581-76-0
  • Molecular Formula: C23H26F2N6O
  • Appearance: white powder
  • Application: For laboratory use only- not intended ...
  • ProductionCapacity: 1 Kilogram/Month
  • Purity: ≥98%
  • Transportation: by air
  • LimitNum: 10 Milligram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

 

 

 

Details

GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors. target: DLK, MAP3K12; IC50: 0.107 uM (DLK); In vitro: . The high dose of inhibitor GNE-3511 resulted in a completesuppression of c-Jun phosphorylation, while the low dose reduced the number of p-c-Jun positive cells to an intermediate level. protected primary neurons in an in vitro axon degeneration assay as well as reduced phosphorylation of the downstream transcription factor c-Jun. In vivo: GNE-3511 exhibites moderate (mouse, rat, and cynomolgus) to high (dog) in vivo plasma clearances, moderate volumes of distribution, short half-lives, and brain penetration sufficient to enable examination in animal models of neurodegeneration.

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