Keywords

• SH5-07
• SH-5-07
• high purity and best price

Quick Details

• ProName: SH5-07 (SH-5-07)
• CasNo: 1456632-41-9
• Molecular Formula: C29H28F5N3O5S
• Appearance: white powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 1 Kilogram/Month
• Purity: ≥98%
• Storage: -20℃
• Transportation: by air
• LimitNum: 10 Milligram

Superiority

Details

SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC₅₀ of 3.9±0.6 μM in in vitro assay. IC50 & Target: IC50: 3.9±0.6 μM (Stat3). In Vitro: SH5-07 is a hydroxamic acid analog of BP-1-102. SH5-07 dose-dependently inhibits Stat3 activity with an IC₅₀ of 3.9±0.6 μM in in vitro assay. It preferentially inhibits Stat3:Stat3 DNA-binding activity, ahead of inhibiting Stat1:Stat3 activity, with minimal effects on Stat1:Stat1 activity. SH5-07 binds Stat3, disrupts Stat3 association with growth factor receptor, and thereby inhibits Stat3 phosphorylation. It induces antitumor cell effects against malignant cells harboring constitutively-active Stat3. SH5-07 inhibits the expression of known Stat3-regulated genes. Bcl-2, Bcl-xL, c-Myc, Survivin, Cyclin D1 and Mcl-1 expression is reduced in response to 24 h, 5 μM SH5-07 treatment. In Vivo: Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm³ established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed.