Keywords

• XMD16-5
• best price
• high purity

Quick Details

• ProName: XMD16-5
• CasNo: 1345098-78-3
• Molecular Formula: C23H24N6O2
• Appearance: off-white powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 1 Kilogram/Quarter
• Purity: ≥98%
• Storage: room temperature
• Transportation: by air
• LimitNum: 1 Gram

Superiority

Details

XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively. IC50 & Target: IC50: 16 nM (TNK2, D163E mutation), 77 nM (TNK2, R806Q mutation). In Vitro: XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD16-5 has IC₅₀s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5