Keywords

• ML324
• best price
• Chengdu Henghui Pharm Tec Co. Ltd

Quick Details

• ProName: ML324 high quality
• CasNo: 1222800-79-4
• Molecular Formula: C21H23N3O2
• Appearance: yellow powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: Metric Ton/Day
• Purity: ≥98%
• Storage: room temperature
• LimitNum: 10 Milligram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details

ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. IC50 value: 920 nM(JMJD2E) [1] Target: JMJD2 demethylase inhibitor ML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.