Keywords

• SRT-2104
• SRT 2104
• SRT2104

Quick Details

• ProName: SRT-2104
• CasNo: 1093403-33-8
• Molecular Formula: C26H24N6O2S2
• Appearance: yellow powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 1 Kilogram/Month
• Purity: ≥98%
• Storage: room temperature
• Transportation: by air
• LimitNum: 10 Milligram

Superiority

Details

SRT 2104 is a small molecule Sirtuin 1 activator. In Vivo: The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)–dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing.SRT 2104 penetrates the blood–brain barrier, attenuates brain atrophy, improves motor function, and extends survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1. SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short–term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. Two SRT2104 clinical trials in elderly volunteers and otherwise healthy smokers show a slight reduction in body weight, a 15–30% improvement in the cholesterol ratio and a 19% decrease in triglyceride levels129,130. A separate study of patients with the inflammatory condition plaque–type psoriasis shows a significant reduction in disease mani–festation following 84 days of oral administration of 500 or 1,000 mg per kg SRT2104