Business Type:Lab/Research institutions
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Country: China (Mainland)
Business Type:Lab/Research institutions
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM. IC50 & Target: Ki: 10 nM (uPA) In Vitro: UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In Vivo: In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.