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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Business Type:Lab/Research institutions

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Main Products:
Year Established:
2017

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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

GSK591

CAS NO.1616391-87-7

  • Min.Order: 10 Milligram
  • Payment Terms:
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Product Details

Keywords

  • GSK591
  • EPZ-015866
  • GSK3203591

Quick Details

  • ProName: GSK591
  • CasNo: 1616391-87-7
  • Molecular Formula: C22H28N4O2
  • Appearance: white powder
  • Application: For laboratory use only- not intended ...
  • ProductionCapacity: 1 Kilogram/Month
  • Purity: ≥99%, ee≥99.5%
  • Storage: room temperature
  • Transportation: by air
  • LimitNum: 10 Milligram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

 

 

 

Details

EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5. It maintained excellent selectivity against other PMT enzymes observed with EPZ015666. IC50:61 nM-904 nM in Maver-1 cells. target: PRMT5 in vitro: A375 cells treated for 18 h with 1 μM EPZ015666 showed stabilization of PRMT5 in cellular thermal shift analysis in whole-cell lysates. In vivo: EPZ015666 or vehicle (0.5% methylcellulose in water) was administered orally BID at a dose volume of 10 mL/kg for 21 d (Granta-519 was dosed for 18 d). 

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