Keywords

• SH-4-54
• best price
• high purity

Quick Details

• ProName: SH-4-54
• CasNo: 1456632-40-8
• Molecular Formula: C29H27F5N2O5S
• Appearance: white powder
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 10 Milligram /Day
• Purity: ≥98%
• Storage: room temperature
• Transportation: by air
• LimitNum: 0 Metric Ton

Superiority

Details

SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1. IC50 value: 300 nM (KD, for STAT3) Target: STAT3 in vitro: SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displayed no toxicity in human fetal astrocytes, potently suppressed pSTAT3 with nanomolar IC50s, inhibited STAT3's downstream targets, and showed no discernible off-target effects at therapeutic doses. in vivo: SH-4-54 exhibits blood-brain barrier permeability, potently controlled glioma tumor growth, and inhibited pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.