Keywords

• darolutamide, ODM-201, BAY-1841788
• BAY-1841788
• high purity ODM-201

Quick Details

• ProName: Darolutamide
• CasNo: 1297538-32-9
• Molecular Formula: C??H??ClN?O?
• Appearance: off-white powder
• Application: just foe experiment.
• Port: shanghai
• ProductionCapacity: 500 Gram/Month
• Purity: 99%
• Storage: -20℃ for 3 years
• LimitNum: 1 Gram
• Related Substances: less than 1%

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

Details

ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.
IC50 value: 26 nM (in AR-HEK293 cells)
Target: androgen receptor
in vitro: ODM-201 is a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. In competitive AR binding assays, the inhibition constant (Ki) values of ODM-201 were 11 nM.
in vivo: ODM-201 inhibits tumor growth in a castration-resistant VCaP xenograft model in vivo. ODM-201 shows a significant antitumor activity with both doses, 50 mg/kg twice daily being more efficacious compared to castrated, untreated mice (p < 0.001).