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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Business Type:Lab/Research institutions

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Year Established:
2017
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Chengdu Henghui Pharmaceutical Co., Ltd.(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

NCGC00244536

CAS NO.2003260-55-5

  • Min.Order: 10 Milligram
  • Payment Terms:
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Product Details

Keywords

  • NCGC00244536
  • KDM4B Inhibitor B3
  • high purity and best price

Quick Details

  • ProName: NCGC00244536
  • CasNo: 2003260-55-5
  • Molecular Formula: C25H22N2O2
  • Appearance: yellow powder
  • Application: For laboratory use only- not intended ...
  • ProductionCapacity: 1 Kilogram/Month
  • Purity: ≥98%
  • Storage: room temperature
  • Transportation: by air
  • LimitNum: 10 Milligram

Superiority

We are a CRO company, and our Research and Development team is consisted of PhDs and Masters in chemistry and pharmacy.

We are committed to protect our customer’s privacy with the highest level of ethical standard. Our dedicated team will follow up on every order and provide instant feedback on the status to our customer.

We stand behind our product by providing a complete QA report. The test data of customer order can be provided upon request.

We make our efforts to offer customer innovative, customized, high-quality service.

Our custom manufacturing encompasses everything from pharmaceutical intermediates to API.

 

 

 

Details

NCGC00244536 is a potent KDM4A inhibitor with an IC50 of 10 nM. IC50 & Target: IC50: 10 nM (KDM4A). In Vitro:NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC50=40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC50s in the sub-micromolar range (Fig. 1D), and abolished androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC50sIn Vivo:Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors had significant amount of cell apoptosis, necrosis, and fibrosis

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