Keywords

• OICR-9429
• OICR 9429
• OICR9429

Quick Details

• ProName: OICR-9429
• CasNo: 1801787-56-3
• Molecular Formula: C29H32F3N5O3
• Application: For laboratory use only- not intended ...
• ProductionCapacity: 1 Kilogram/Month
• Purity: ≥98%
• Storage: room temperature
• Transportation: For laboratory use only- not intended ...
• LimitNum: 10 Milligram

Superiority

Details

OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBPα mutations by about 50% (mean value, n = 8) at 5 μM [2] In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.